A full list of Drug Stability publications can be found on the BSAC OPAT website
This forum exists to foster exchange of open access information between organisations globally who are working on drug stability testing for medicines used to treat infectious disease.
To discuss commissioning a study, and for further information on costs and timescale, please contact Felicity Drummond at OPAT@bsac.org.uk. The aim of the project is to obtain where possible positive stability data in appropriate medical devices enabling OPAT teams to adhere to the principles of antimicrobial stewardship in both OPAT and in-patient settings.
” The outcomes of the stability tests undertaken will not be a simple pass or fail. On identifying a compound with sub-optimal stability our teams of experts will endeavour to understand the mechanism for degradation leading to lack of stability. Due to the nature of antimicrobial agents many are unstable compounds with pH playing a key role in the speed of degradation. Stability can frequently be improved by maintaining the compounded solutions pH within fixed parameters. This is achieved by the addition of small quantities of commercially available buffers, compounds that maintain the pH of a solution within certain boundaries. Following identification of appropriate buffer, additional stability testing will be completed in appropriate administration devices. It is envisaged that this method of testing will to optimise the medicines, doses, regimens and durations available to OPAT teams. Organisations commissioning studies will, in most instances, receive advice and peer review publication on how to prepare and ensure stability of their agent.